版权所有：国产探花-国产探花视频-av探花

闫福华

电话：025-83620107邮箱：[email protected] 地址：研究方向：

组织工程与牙周再生治疗；牙周病与全身系统性疾病的关系；牙周病的种植修复治疗等

闫福华，主任医师、教授、博士国产探花导师、版权所有：国产探花-国产探花视频-av探花附属口腔医院副院长。1985年毕业于遵义国产探花口腔医学系，获医学学士学位；1993年毕业于北京医科大学口腔国产探花（现北京大学），获医学博士学位，1998年国家公派访问学者赴澳大利亚昆士兰大学牙国产探花进行组织工程与牙周再生治疗的研究。曾任福建医科大学口腔国产探花及福建医科大学附属口腔医院院长、福建医科大学国产探花国产探花国产探花院长、福建省口腔医学会首任及第二届会长、江苏省口腔医学会牙周病学专业委员会首任主任委员、武汉大学兼职教授、博士生导师。现任版权所有：国产探花-国产探花视频-av探花附属口腔医院副院长、博士国产探花导师，享受国务院政府特殊津贴,中华口腔医学会牙周病学专业委员会主任委员、江苏省口腔医学会副会长, “十三五”规划教材《牙周病学》副主编，江苏省“双创计划”人才，江苏省“特聘医学专家”，江苏省“六大人才高峰”高层次人才等荣誉。主要研究领域为组织工程与牙周再生治疗、牙周病与全身系统性疾病的关系、牙周病的种植修复治疗等。先后主持省部级及以上国产探花项目18项（其中国家自然科学基金项目7项），发表论文300余篇（其中International Journal of Oral Science, Journal ofDentalResearch, Journal of Clinical Periodontology, Journal of Periodontology，Journal of Periodontal Research，Advanced Healthcare Materials，Bioactive materials，Biomaterials, Theranostics，AppliedMaterials Today等国产探花刊物 80余篇）。主编、主译国产探花专著26部。获国产探花部科技进步奖二等奖1项（1/15），江苏省医学新技术引进一等奖1项（1/3）。福建省科学技术进步奖二等奖1项（1/5），福建省国产探花成果奖二等奖1项（2/6）。已培养毕业博士28人、硕士55人。现正指导博士后4人、在读博士国产探花 6人、硕士国产探花 6人。

1.中华口腔医学会牙周病学专业委员会主任委员

2.中华口腔医学会理事

3.江苏省口腔医学会副会长

4.中华口腔医学杂志编委

5. International Journal of Oral Science编委

6. Frontiers in Dental Medicine编委

1.Bao J, Li L, Zhang Y, Wang M, Chen F, Ge S, Chen B*, Yan F*. Periodontitis may induce gut microbiota dysbiosis via salivary microbiota[J]. Int J Oral Sci. 2022,14(1):32. (IF:24.897)

2.Lu J, Zhang S, Huang Y, Qian J, Tan B, Qian X, Zhuang J, Zou X, Li Y*, Yan F*. Periodontitis-related salivary microbiota aggravates Alzheimer's disease via gut-brain axis crosstalk[J]. Gut Microbes. 2022,14(1):2126272. (IF:9.434)

3.Qian J, Lu J, Huang Y, Wang M, Chen B, Bao J, Wang L, Cui D, Luo B, Yan F*. Periodontitis salivary microbiota worsens colitis[J]. J Dent Res. 2021,2021;220345211049781. (IF:8.924)

4.Li L, Wang M, Bao J, Wang N, Huang Y, He S, Chen B*, Yan F*. Periodontitis may impair the homeostasis of systemic bone through regulation of gut microbiota in ApoE-/- mice[J]. J Clin Periodontol. 2022 Jul 24. doi: 10.1111/jcpe.13708. (IF:7.478)

5.Liao Y, Zhang M, Lin X*, Yan F*. Diaryl urea derivative molecule inhibits cariogenic Streptococcus mutans by affecting exopolysaccharide synthesis, stress response and nitrogen metabolism[J]. Front Cell Infect Microbiol. 2022,12:904488. (IF:6.073)

6.Qiao D, Chen R, Li L, Zhu F, Zhang Y*, Yan F*. Accelerated alveolar bone loss in a mouse model of inflammatory bowel disease and its relationship with intestinal inflammation[J]. J Periodontol. 2022,1-12. (IF:6.993)

7.Wang N, Zheng L, Qian J, Wang M, Li L, Huang Y, Zhang Q, Li Y*, Yan F*. Salivary microbiota of periodontitis aggravates bone loss in ovariectomized rats. Front Cell Infect Microbiol. 2022,12:983608. (IF:6.073)

5.Zhang M, Liao Y, Tong X*, Yan F*. Novel urea derivative-loaded PLGA nanoparticles to inhibit caries-associated Streptococcus mutans[J]. RSC Adv. 2022,12:4072-4080. (IF:3.361)

6.Liao Y, Zhou C, Zhang Q, Wang X, Yan F*, Xing X*. Prevalence of early childhood caries in three regions of China: a cross-sectional study[J]. Int J Paediatr Dent. 2022,00:1-12. (IF:3.455)

8.Cui D, Kong N, Ding L, Guo Y*, Yang W*, Yan F*. Ultrathin 2D Titanium Carbide MXene (Ti₃C₂T_x) nanoflakes activate WNT/HIF-1alpha-mediated metabolism reprogramming for periodontal regeneration[J]. Adv Healthc Mater. 2021,2101215. (IF:9.933)

9.Zhang S, Zhou H, Kong N, Wang Z, Fu H, Zhang Y, Xiao Y*, Yang W*, Yan F*. L-cysteine-modified chiral gold nanoparticles promote periodontal tissue regeneration[J]. Bioact Mater. 2021,6:3288-3299. (IF:14.593)

10.Li L, Bao J, Chang Y, Wang M, Chen B*, Yan F*. Gut microbiota may mediate the influence of periodontitis on prediabetes[J]. J Dent Res. 2021,2021; 220345211009449. (IF:6.116)

11.Zhang Y, Wang P, Wang Y, Li J, Qiao D, Chen R, Yang W, Yan F*. Gold nanoparticles promote the bone regeneration of periodontal ligament stem cell sheets through activation of autophagy[J]. Int J Nanomedicine. 2021,16:61-73. (IF:5.115)

12.Cui D, Chen C, Luo B, Yan F*. Inhibiting PHD2 in human periodontal ligament cells via lentiviral vector-mediated RNA interference facilitates cell osteogenic differentiation and periodontal repair[J]. J Leukoc Biol. 2021,1-11. (IF:4.962)

13.Li P, Zhang Y, Yan F*, Zhou X*. Characteristics of a bacteriophage, vB_Kox_ZX8, isolated from clinical klebsiella oxytoca and its therapeutic effect on mice bacteremia[J]. Front. Microbiol. 2021,12:763136. (IF:5.64)

14.Chen R, Qiao D, Wang P, Li L, Zhang Y*, Yan F*. Gold nanoclusters exert bactericidal activity and enhance phagocytosis of macrophage mediated killing of Fusobacterium nucleatum[J]. Front. Mater. 2021,8:803871. (IF:3.515)

15.Wang X, Ye P, Fang L, Ge S, Huang F, Polverini PJ, Heng W, Zheng L, Hu Q*, Yan F*, Wang W*. Active smoking induces aberrations in digestive tract microbiota of rats[J]. Front. Cell. Infect. Microbiol. 2021,11:737204. (IF:5.293)

16.Li Y, Du Z, Xie X, Zhang Y, Liu H, Zhou Z, Zhao J, Lee RS, Xiao Y, Ivanoviski S, Yan F*. Epigenetic changes caused by diabetes and their potential role in the development of periodontitis[J]. J Diabetes Investig. 2021,12(8):1326-1335. (IF:3.761)

17.Zhang Y, Qiao D, Chen R, Zhu F, Gong J, Yan F*. The association between periodontitis and inflammatory bowel disease: a systematic review and Meta-analysis[J]. Biomed Res Int. 2021:6692420. (IF:3.411)

18.Li L, Zhang Y, Wang M, Zhou J, Zhang Q, Yang W*, Li Y*, Yan F*. gold nanoparticles combined human β-defensin 3 gene-modified human periodontal ligament cells alleviate periodontal destruction via the p38 MAPK pathway[J]. Front Bioeng Biotechnol. 2021,9:631191. (IF:3.644)

19.Qian X, Zhang S, Duan L, Yang F, Zhang K, Yan F*, Ge S*. Periodontitis deteriorates cognitive function and impairs neurons and glia in a mouse model of Alzheimer's disease[J]. J Alzheimers Dis. 2021,79(4):1785-1800. (IF:4.472)

20.Huang Y, Liao Y, Luo B, Li L, Zhang Y, Yan F*. Non-surgical periodontal treatment restored the gut microbiota and intestinal barrier in Apolipoprotein E-/- mice with periodontitis[J]. Front Cell Infect Microbiol. 2020,10:498. (IF:4.123)

21.Li L, Jiang H, Chen R, Zhou J, Xiao Y, Zhang Y*, Yan F*. Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis[J]. Int J Oral Sci. 2020,12(1):13. (IF:3.047)

22.Zhang S, Yang F, Wang Z, Qian X, Ji Y, Gong L, Ge S*, Yan F*. Poor oral health conditions and cognitive decline: Studies in humans and rats[J]. PLoS One. 2020,15(7): e0234659. (IF:2.74)

23.Ni C, Zhou J, Kong N, Bian T, Zhang Y, Huang X, Xiao Y*, Yang W*, Yan F*. Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment[J]. Biomaterials. 2019,206:115-132. (IF:10.273)

24.Zhang Q, Chen L, Chen B, Chen C, Chang J, Xiao Y, Wu C, Yan F*. Lithium-calcium-silicate bioceramics stimulating cementogenic/osteogenic differentiation of periodontal ligament cells and periodontal regeneration[J]. Appl Mater Today. 2019,16:375-387. (IF:8.013)

25.Liu J, Chen B, Bao J, Zhang Y, Lei L*, Yan F*. Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration[J]. Stem Cell Res Ther. 2019,10(1):320. (IF:4.627)

26.Zhou J, Zhang Y, Li L, Fu H, Yang W, Yan F*. Human β-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments[J]. Int J Nanomedicine. 2018,13:555-567. (IF:4.471)

27.Chen B, Ni Y, Liu J, Zhang Y, Yan F*. Bone marrow-derived mesenchymal stem cells exert diverse effects on different macrophage subsets[J]. Stem Cells Int. 2018,2018:8348121. (IF:3.902)

28.钱俊,张杨珩,程书瑜,王南南,郑丽纯,李丽丽,闫福华.牙周炎患者唾液菌群对小鼠色氨酸-芳香烃受体信号轴的影响[J].中华口腔医学杂志,2022,57(6):40-48.

29.王敏,张杨珩,闫福华.牙周炎与代谢综合征关系的研究进展[J].中华口腔医学杂志,2021,56(11):1138-1143.

30.谭葆春,闫福华. 控制菌斑和炎症在牙龈肥大治疗中的效果评价[J].中华口腔医学杂志,2021,56(6):510-516.

31.李丽丽,保珺,陈斌,闫福华. 高脂饮食加重牙周炎对肠道菌群及糖代谢影响的实验研究[J].中华口腔医学杂志,2021,56(6):539-548.

32.陈斌,李丽丽,张倩,刘娟,程群,闫福华. 侵袭性牙周炎、慢性牙周炎与牙周健康者龈下菌群的差异研究[J].中华口腔医学杂志,2020,55(07):466-474.

1.国家自然科学基金项目面上项目，牙周炎介导的肠道菌群紊乱通过色氨酸-AhR信号轴调控雌激素缺乏状态下牙槽骨吸收的机制研究，82270979，2023/01-2026/12，主持，在研。

2.江苏省重点研发计划社会发展面上项目，利用肠道菌群调控色氨酸-AhR信号轴治疗高脂肥胖状态下牙槽骨吸收的研究，BE2022670，2022/07-2025/06，主持，在研。

3.国家自然科学基金项目，牙周致病菌肠道异位定植对高脂血症状态下骨免疫微环境和骨重建的影响及其机制研究，81970939，2020/01-2023/12，主持，在研。

1. 2021年指导的张爽博士《手性金纳米颗粒调节自噬促进骨再生的研究》被评为“2021年度国产探花优秀博士学位论文”；

2. 2020年《牙周炎对口腔和全身健康的危害及其关键防治技术的研究和推广》项目获得“国产探花部高等学校科学研究优秀成果奖（科学技术进步奖）二等奖”（1/15）;

3. 2020年《微创牙周诊疗技术在重度牙周炎患牙保存中的应用》项目获得“江苏省新技术引进奖一等奖”（1/3）；

4. 2010年《组织工程技术用于治疗牙周疾病的实验与临床研究》项目获得“福建省科学技术进步奖二等奖”（1/5）；

5.2009年《立足海西建设需要培养口腔医学人才》成果获“福建省国产探花成果奖”二等奖）（2/6）。